Tuberculosis vaccine development: Shifting focus amid increasing development challenges
نویسندگان
چکیده
منابع مشابه
μÀÑ Vaccine development for Tuberculosis: Past, Present and Future Challenges
About one third of the world's population is infected with Mycobacterium tuberculosis (M. tb), and new infections occur at a rate of about one per second. Additionally, more people in the developed world contact tuberculosis (TB) because their immune systems are more likely to be compromised due to higher exposure to immunosuppressive drugs, substance abuse, or AIDS. The distribution of tubercu...
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Tuberculosis caused by Mycobacterium bovis in domestic livestock and wildlife is a significant problem in many countries worldwide. Wildlife reservoirs of tuberculosis confound programs for tuberculosis eradication from domestic livestock. Successful vaccination against tuberculosis in domestic animals or wildlife could contribute to tuberculosis eradication. Bacille Calmette-Guérin (BCG) has b...
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Information derived from the complete genome sequence of Mycobacterium tuberculosis makes it possible to develop a range of new vaccine candidates. Strategies currently under investigation include construction of whole cell live attenuated mycobacterial vaccines, as well as the use of individual antigens delivered by a variety of subunit vaccination procedures. Fundamental questions associated ...
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Influenza viruses continue to be a major health threat in human and bird populations. The improvements in formulation and production level of the current influenza vaccines are not sufficient to afford complete protection. The continuous antigenic drifts and emergence of endemic and zoonotic strains make influenza vaccine planning difficult. Concern about the emergence of new influenza pandemic...
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Tuberculosis remains a major public health problem around the world. Because the Mycobacterium bovis Bacilli-Calmette-Guerin (BCG) vaccine fails to protect adults from pulmonary tuberculosis, there is an urgent need for improved vaccine formulations. Unlike BCG, recombinant vaccines purified from bacterial expression vectors, as well as naked DNA, require an additional adjuvant. Recent improvem...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2015
ISSN: 2164-5515,2164-554X
DOI: 10.1080/21645515.2015.1040955